ELK Biotechnology C/EBP α (phospho Ser21) rabbit pAb
C/EBP α (phospho Ser21) rabbit pAb는 인산화된 C/EBPα 단백질을 검출하기 위한 고품질 폴리클로날 항체입니다. WB, IHC, IF, ELISA 등 다양한 응용에 적합하며, 인간, 생쥐, 랫드 반응성을 보입니다. -20°C에서 장기 보관 가능합니다.
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제품명
C/EBP α (phospho Ser21) rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | CEBPA; CCAAT/enhancer-binding protein alpha; C/EBP alpha |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human C/EBP-alpha around the phosphorylation site of Ser21. AA range: 6–55 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 42 kDa |
| Gene ID (Human) | 1050 |
| Human Swiss-Prot No | P49715 |
| Cellular Localization | Nucleus; [Isoform 4]: Nucleus, nucleolus |
| Species Reactivity | Human; Mouse; Rat |
배경 정보
This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons. [provided by RefSeq, Dec 2013]
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