ELK Biotechnology Smad3 (phospho Ser425) rabbit pAb
Smad3 단백질의 Ser425 인산화 부위를 인식하는 토끼 다클론 항체. IF, WB, IHC, ELISA 등 다양한 응용에 적합. Human, Mouse, Rat 반응성. 1 mg/ml 농도, -20°C에서 1년 보관 가능. 세포 내 위치 연구 및 TGF-β 신호전달 연구에 활용.
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Smad3 (phospho Ser425) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Smad3 (phospho Ser425) rabbit pAb |
| Alternative Names | SMAD3; MADH3; Mothers against decapentaplegic homolog 3; MAD homolog 3; Mad3; Mothers against DPP homolog 3; hMAD-3; JV15-2; SMAD family member 3; SMAD 3; Smad3; hSMAD3 |
| Applications | IF; WB; IHC; ELISA |
| Recommended Dilutions | IF: 1:50–200; WB: 1:500–1:2000; IHC: 1:100–1:300; ELISA: 1:40000 (Not yet tested in other applications) |
| Immunogen | Synthesized peptide derived from human Smad3 around the phosphorylation site of Ser425 (AA range: 376–425) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 58 kDa |
| Gene ID (Human) | 4088 |
| Human Swiss-Prot No. | P84022 |
| Species Reactivity | Human; Mouse; Rat |
Cellular Localization
Cytoplasm and nucleus. Cytoplasmic and nuclear in the absence of TGF-β. Upon TGF-β stimulation, migrates to the nucleus when complexed with SMAD4 (PubMed:15799969, 21145499). Released from the SMAD2/SMAD4 complex via PPM1A and exported from the nucleus through interaction with RANBP1 (PubMed:16751101, 19289081). Co-localizes with LEMD3 at the nuclear inner membrane (PubMed:15601644). MAPK-mediated phosphorylation has no effect on nuclear import (PubMed:19218245). PDPK1 prevents nuclear translocation in response to TGF-β (PubMed:17327236). Localized mainly to the nucleus in early embryonic development, later evident in cytoplasm of inner cell mass at the blastocyst stage (By similarity).
Background
The protein encoded by this gene belongs to the SMAD family, which includes proteins similar to the Drosophila gene mothers against decapentaplegic (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators mediating multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta (TGF-β) and is thought to play a role in carcinogenesis regulation.
[Provided by RefSeq, Apr 2009]
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