ELK Biotechnology SH-PTP2 (phospho Tyr580) rabbit pAb
SHP-2 단백질의 Tyr580 인산화 부위를 인식하는 rabbit polyclonal antibody. WB, IHC, IF, ELISA에 사용 가능하며, 다양한 세포 신호 조절 연구에 적합. Human, Mouse, Rat 반응성. -20°C에서 1년 보관.
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제품명
SH-PTP2 (phospho Tyr580) rabbit pAb
제품 개요
이 항체는 인간 SHP-2 단백질의 Tyr580 인산화 부위를 기반으로 제작된 rabbit polyclonal antibody입니다. 단백질 인산화 조절, 세포 신호전달 및 암 관련 연구에 유용합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | PTPN11; PTP2C; SHPTP2; Tyrosine-protein phosphatase non-receptor type 11; Protein-tyrosine phosphatase 1D; PTP-1D; Protein-tyrosine phosphatase 2C; PTP-2C; SH-PTP2; SHP-2; Shp2; SH-PTP3 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human SHP-2 around the phosphorylation site of Tyr580 (AA range: 546–595) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 70 kD |
| Gene ID (Human) | 5781 |
| Human Swiss-Prot No. | Q06124 |
| Cellular Localization | Cytoplasm, Nucleus |
| Species Reactivity | Human, Mouse, Rat |
Background
The protein encoded by this gene belongs to the protein tyrosine phosphatase (PTP) family, which regulates various cellular processes such as cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains that act as phospho-tyrosine binding domains, mediating interactions with substrates. It is widely expressed across tissues and plays a key regulatory role in cell signaling events including mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are associated with Noonan syndrome and acute myeloid leukemia (RefSeq, Aug 2016).
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