ELK Biotechnology AMPKα1/2 (phospho Thr183/172) rabbit pAb
AMPKα1/2 인산화형(Thr183/172)을 인식하는 rabbit polyclonal antibody로, 세포 에너지 대사 및 스트레스 반응 연구에 적합. IF, WB, IHC, ELISA 등 다양한 응용 가능. 고순도 IgG, 세포질 및 핵에서 발현 검출.
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제품명
AMPKα1/2 (phospho Thr183/172) rabbit pAb
공급업체
ELK Biotechnology
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | PRKAA1; AMPK1; 5'-AMP-activated protein kinase catalytic subunit alpha-1; AMPK subunit alpha-1; Acetyl-CoA carboxylase kinase; ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase; Tau-protein kinase PRKAA1; PRKAA2; AMPK |
| Applications | IF; WB; IHC; ELISA |
| Recommended Dilutions | IF: 1:50–200; Western Blot: 1:500–1:2000; Immunohistochemistry: 1:100–1:300; ELISA: 1:40000; Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human AMPK alpha around phosphorylation site Thr172 (AA range: 140–189) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 63 kD |
| GeneID (Human) | 5562 / 5563 |
| Human Swiss-Prot No | Q13131 / P54646 |
| Cellular Localization | Cytoplasm, Nucleus; in response to stress, recruited by p53/TP53 to specific promoters |
| Species Reactivity | Human; Mouse; Rat; Monkey; Pig |
Background
The protein encoded by this gene belongs to the serine/threonine protein kinase family and acts as the catalytic subunit of the 5'-AMP-activated protein kinase (AMPK). AMPK functions as a cellular energy sensor conserved across eukaryotic cells. Its kinase activity is triggered by stimuli that elevate the cellular AMP/ATP ratio. AMPK regulates key metabolic enzymes through phosphorylation, protecting cells from ATP depletion by inhibiting ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
(Provided by RefSeq, Jul 2008)
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