ELK Biotechnology ERK 1/2 (phospho Tyr222/205) rabbit pAb

제품명

ERK 1/2 (phospho Tyr222/205) rabbit pAb

제품 개요

본 항체는 인간 ERK 1/2 단백질의 인산화 부위(phospho Tyr222/205)를 인식하는 rabbit polyclonal antibody입니다. MAPK 신호전달 경로 연구 및 세포 내 인산화 상태 분석에 유용합니다.

제품 정보

Background

This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported.