ELK Biotechnology Smad3 (phospho Ser204) rabbit pAb
Smad3 (phospho Ser204) rabbit polyclonal antibody로 TGF-β 신호전달 관련 단백질 연구에 적합. WB, IHC, IF, ELISA 등 다양한 응용 가능. 인간, 생쥐, 랫트 반응성. 고순도 IgG, 1 mg/ml 농도, -20°C에서 1년 보관.
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제품명
Smad3 (phospho Ser204) rabbit pAb
공급업체
ELK Biotechnology
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | SMAD3; MADH3; Mothers against decapentaplegic homolog 3; MAD homolog 3; Mad3; Mothers against DPP homolog 3; hMAD-3; JV15-2; SMAD family member 3; SMAD 3; Smad3; hSMAD3 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 Immunofluorescence: 1/200–1/1000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Smad3 around the phosphorylation site of Ser204 (AA range: 170–219) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 48 kD |
| GeneID (Human) | 4088 |
| Human Swiss-Prot No | P84022 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치
Cytoplasm and nucleus. Cytoplasmic and nuclear in the absence of TGF-beta. Upon TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 (PubMed:15799969, PubMed:21145499). Released from the SMAD2/SMAD4 complex by phosphatase PPM1A and exported out of the nucleus via RANBP1 interaction (PubMed:16751101, PubMed:19289081). Co-localizes with LEMD3 at the nuclear inner membrane (PubMed:15601644). MAPK-mediated phosphorylation appears to have no effect on nuclear import (PubMed:19218245). PDPK1 prevents nuclear translocation in response to TGF-beta (PubMed:17327236). Localized mainly to the nucleus in early embryo development, later evident in cytoplasm of inner cell mass at blastocyst stage (By similarity).
배경 정보
The protein encoded by this gene belongs to the SMAD family, similar to the Drosophila gene mothers against decapentaplegic (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators mediating multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in carcinogenesis. [RefSeq, Apr 2009]
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