ELK Biotechnology PPAR-γ (phospho Ser112) rabbit pAb
PPAR-γ 인산화(Ser112) 부위를 인식하는 토끼 다클론 항체로, 인간·마우스·랫트에 반응합니다. Western blot과 ELISA에 적합하며, 세포 내 PPAR-γ의 발현 및 인산화 상태 분석에 유용합니다. -20°C에서 1년 보관 가능합니다.
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제품명
PPAR-γ (phospho Ser112) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | PPARG; NR1C3; Peroxisome proliferator-activated receptor gamma; PPAR-gamma; Nuclear receptor subfamily 1 group C member 3 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human PPAR-gamma around the phosphorylation site of Ser112. AA range: 78–127 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 60 kD |
| Gene ID (Human) | 5468 |
| Human Swiss-Prot No. | P37231 |
| Cellular Localization | Nucleus, Cytoplasm. Redistributed from the nucleus to the cytosol through a MAP2K1/MEK1-dependent manner. NOCT enhances its nuclear translocation. |
| Species Reactivity | Human; Mouse; Rat |
Background
Peroxisome proliferator activated receptor gamma (PPARG) Homo sapiens.
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma.
The protein encoded by this gene, PPAR-gamma, regulates adipocyte differentiation and has been implicated in diseases such as obesity, diabetes, atherosclerosis, and cancer. Alternatively spliced transcript variants encoding different isoforms have been described.
[provided by RefSeq, Jul 2008]
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