ELK Biotechnology Cyclin D1 (phospho Thr286) rabbit pAb
Cyclin D1 (phospho Thr286) rabbit polyclonal antibody로, 인산화된 Thr286 부위에 특이적으로 결합합니다. WB, IHC, IF, ELISA에 적합하며 인간, 마우스, 랫트 시료에 반응합니다. 세포주기 조절 연구 및 종양 관련 단백질 분석에 유용합니다.
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Cyclin D1 (phospho Thr286) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Cyclin D1 (phospho Thr286) rabbit pAb |
| Alternative Names | CCND1; BCL1; PRAD1; G1/S-specific cyclin-D1; B-cell lymphoma 1 protein; BCL-1; BCL-1 oncogene; PRAD1 oncogene |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 ELISA: 1/10000 Other applications not yet tested |
| Immunogen | Synthesized peptide derived from human Cyclin D1 around phosphorylation site of Thr286 (AA range: 246–295) |
| Host | Rabbit |
| Storage | -20°C for 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 33 kDa |
| Gene ID (Human) | 595 |
| Human Swiss-Prot No. | P24385 |
| Cellular Localization | Nucleus, Cytoplasm, Nuclear membrane. Cyclin D–CDK4 complexes accumulate at the nuclear membrane and translocate to the nucleus through interaction with KIP/CIP family members. |
| Species Reactivity | Human, Mouse, Rat |
Background
The protein encoded by this gene belongs to the highly conserved cyclin family, characterized by periodic changes in protein abundance throughout the cell cycle. Cyclins regulate CDK kinases, and distinct cyclins show specific expression and degradation patterns that coordinate mitotic events. Cyclin D1 forms a complex with CDK4 or CDK6, essential for G1/S transition, and interacts with tumor suppressor protein Rb. Its expression is positively regulated by Rb. Mutations, amplification, and overexpression of this gene are frequently observed in various tumors and may contribute to tumorigenesis.
(Provided by RefSeq, Jul 2008)
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