ELK Biotechnology p53 (phospho Ser37) rabbit pAb
p53의 Ser37 인산화 부위를 인식하는 토끼 다클론 항체로, WB, IHC, IF, ELISA에 사용 가능. 인간, 생쥐, 랫트 시료에 반응하며 세포 내 p53 단백질의 위치 및 발현 연구에 적합. -20°C에서 1년 보관 가능.
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제품명
p53 (phospho Ser37) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | TP53; P53; Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human p53 around the phosphorylation site of Ser37 (AA range: 11–60) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 44 kD |
| Gene ID (Human) | 7157 |
| Human Swiss-Prot No. | P04637 |
| Species Reactivity | Human; Rat; Mouse |
세포 내 위치 (Cellular Localization)
Cytoplasm, Nucleus, PML body, Endoplasmic reticulum, Mitochondrion matrix, Cytoskeleton (microtubule organizing center, centrosome).
Recruited into PML bodies together with CHEK2 (PubMed:12810724).
Translocates to mitochondria upon oxidative stress (PubMed:22726440) and in response to mitomycin C treatment (PubMed:27323408).
- Isoform 1: Predominantly nuclear; localizes to cytoplasm when expressed with isoform 4
- Isoform 2: Mainly nuclear with minor cytoplasmic staining
- Isoform 3: Nuclear in most cells, cytoplasmic in some
- Isoform 4: Predominantly nuclear but translocates to cytoplasm
배경 정보 (Background)
Tumor protein p53 (TP53) is a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains.
It responds to cellular stress by regulating target genes involved in cell cycle arrest, apoptosis, senescence, DNA repair, and metabolism.
Mutations in TP53 are associated with various human cancers, including hereditary Li-Fraumeni syndrome.
Alternative splicing and promoter usage generate multiple transcript variants and isoforms.
Additional isoforms may arise from alternate translation initiation codons (PMIDs: 12032546, 20937277).
[Provided by RefSeq, Feb 2013]
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