ELK Biotechnology CaMKIIα/β/δ (phospho Thr305) rabbit pAb
CaMKIIα/β/δ (phospho Thr305) rabbit polyclonal antibody로, 인산화된 Thr305 부위를 인식합니다. WB, IHC, IF, ELISA에 사용 가능하며 인간, 마우스, 랫트 시료에 반응합니다. 고순도 IgG, 1 mg/ml 농도로 제공되며 -20°C에서 1년 보관 가능합니다.
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제품명
CaMKIIα/β/δ (phospho Thr305) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | CAMK2A; CAMKA; KIAA0968; Calcium/calmodulin-dependent protein kinase type II subunit alpha; CaM kinase II subunit alpha; CaMK-II subunit alpha; CAMK2B; CAM2; CAMK2; CAMKB; Calcium/calmodulin-dependent protein kinase type II subunit beta |
| Applications | WB, IHC, IF, ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 ELISA: 1/5000 Other applications not yet tested |
| Immunogen | Synthesized peptide derived from human CaMK2 α/β/δ around the phosphorylation site of Thr305 (AA range: 271–320) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 54 kDa |
| Gene ID (Human) | 816 / 817 |
| Human Swiss-Prot No. | Q9UQM7 / Q13554 / Q13557 |
| Cellular Localization | Cell junction, synapse, postsynaptic density, dendritic spine, dendrite, postsynaptic lipid rafts |
| Species Reactivity | Human, Mouse, Rat |
Background
This gene encodes a member of the serine/threonine protein kinases family and belongs to the Ca²⁺/calmodulin-dependent protein kinases subfamily. Calcium signaling plays a critical role in synaptic plasticity at glutamatergic synapses. The kinase consists of four subunits: α, β, γ, and δ. The α chain is essential for hippocampal long-term potentiation (LTP) and spatial learning. In addition to CaM-dependent activity, this protein can undergo autophosphorylation, leading to CaM-independent activation. Two transcript variants encoding distinct isoforms have been identified (RefSeq, Nov 2008).
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