ELK Biotechnology Stat6 (phospho Thr645) rabbit pAb
STAT6 (phospho Thr645) rabbit polyclonal antibody로, IL-4 신호전달 및 STAT6 인산화 연구에 적합합니다. WB, IHC, IF, IP, ELISA에 사용 가능하며, 사람·마우스·랫트 시료에 반응합니다. 고농도(1 mg/ml) IgG 형식으로 -20°C에서 1년 보관 가능합니다.
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제품명
Stat6 (phospho Thr645) rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | STAT6; Signal transducer and activator of transcription 6; IL-4 Stat |
| Applications | WB; IHC; IF; IP; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 Immunoprecipitation: 2–5 µg/mg lysate ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human STAT6 around the phosphorylation site of Thr645 (AA range: 612–661) |
| Storage | -20°C / 1 year |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| GeneID (Human) | 6778 |
| Human Swiss-Prot No | P42226 |
| Cellular Localization | Cytoplasm; Nucleus. Translocated into the nucleus in response to phosphorylation |
| Species Reactivity | Human; Mouse; Rat |
배경 설명
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by receptor-associated kinases and form homo- or heterodimers that translocate to the nucleus, acting as transcription activators.
STAT6 plays a central role in IL-4 mediated biological responses and induces BCL2L1/BCL-X(L) expression, contributing to anti-apoptotic activity. Mouse knockout studies indicate its involvement in Th2 cell differentiation, surface marker expression, and immunoglobulin class switching.
Alternative splicing results in multiple transcript variants. [RefSeq, May 2010]
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