Thermo Fisher Scientific SLC30A8 Polyclonal Antibody
인간 SLC30A8 단백질을 인식하는 sheep polyclonal 항체로, IHC(P)에서 5–15 µg/mL 농도로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 동결건조 형태로 제공. 췌장 베타세포 연구 및 제2형 당뇨 관련 연구에 적합.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 5–15 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived recombinant human ZnT-8 (Lys268–Pro359) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2606835 |
Product Specific Information
Reconstitute in sterile PBS to a final concentration of 0.2 mg/mL before use.
Target Information
SLC30A8 (ZnT-8) is a zinc efflux transporter involved in zinc accumulation within intracellular vesicles. It is highly expressed in the pancreas, particularly in the islets of Langerhans, and co-localizes with insulin in secretory granules of insulin-secreting INS-1 cells.
Allelic variants of SLC30A8 are major genetic risk factors for Type 2 diabetes, while no association has been identified with Type 1 diabetes. Expression in β-cells is influenced by cytokines such as IFN-γ and IL-1β.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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