Thermo Fisher Scientific SLC30A8 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

5-15 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Sheep / IgG

Class

Polyclonal

Type

Antibody

Immunogen

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS with 5% trehalose

Contains

No Preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2606835

Product Specific Information

Reconstitute in sterile PBS to a final concentration of 0.2 mg/mL.

Target Information

Slc30A8 is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles and is expressed at a high level in the pancreas, particularly in islets of Langerhans, and co-localizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of Slc30A8 have been identified as major genetic risk factors for the development of Type 2 diabetes, but no genetic association has been found with Type 1 diabetes. Slc30A8 expression in b-cells was found to be influenced by cytokine expression, particularly IFN-gamma and IL-1 beta.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.