Thermo Fisher Scientific CD44 Monoclonal Antibody (8E2F3)
CD44 단백질을 검출하는 Thermo Fisher Scientific의 Mouse Monoclonal Antibody (Clone 8E2F3). WB, IHC, ICC, Flow, ELISA 등 다양한 응용에 적합. Human 및 Mouse 시료 반응성. 82kDa CD44 검출에 최적화된 연구용 항체.
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- MA515462
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 | – |
| Immunocytochemistry (ICC/IF) | 1:200–1:1,000 | View 3 publications |
| Flow Cytometry (Flow) | 1:200–1:400 | – |
| ELISA | 1:10,000 | – |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 8E2F3 |
| Immunogen | Purified recombinant fragment of human CD44 (628–699) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Buffer | Ascites |
| Contains | 0.03% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_10981151 |
Product Specific Information
MA5-15462 targets CD44 in indirect ELISA, FACS, IF, IHC, and WB applications and shows reactivity with human and mouse samples.
The immunogen is a purified recombinant fragment of human CD44 (amino acids 628–699) expressed in E. coli.
MA5-15462 detects CD44 with a predicted molecular weight of approximately 82 kDa.
Target Information
CD44 is a 100 kDa type I transmembrane glycoprotein widely expressed on human leukocytes, white matter of the brain, and some epithelial cells of the intestine and breast.
Several isoforms exist, including the predominant CD44H isoform found in many normal tissues.
CD44 acts as a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, adhesion, and migration.
It participates in lymphocyte activation, recirculation, and homing. Expression may be up-regulated in carcinomas, potentially related to metastatic potential.
CD44 is expressed by hematopoietic and non-hematopoietic cells, epithelial tissues, and filopodia in cultured keratinocytes.
Bone marrow myeloid cells and memory T cells express high levels, and peripheral B and T cells can upregulate CD44 in response to stimulation.
Transcripts undergo complex alternative splicing, producing diverse isoforms.
Diseases associated with CD44 dysfunction include superficial keratitis and lichen sclerosus, and CD44 may be related to tumor metastasis formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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