Thermo Fisher Scientific Androgen receptor Polyclonal Antibody
Androgen receptor를 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC, ELISA 등 다양한 응용에 적합. 인간, 마우스, 랫, 피그, 고트 시료 반응. Protein A 정제, 1 mg/mL 농도, -20°C 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:500 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Goat, Human, Mouse, Pig, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human AR (amino acids 825–919) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. The receptor (~90 kDa) has three major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. It is a ligand-activated transcription factor that binds testosterone (T) and dihydrotestosterone (DHT). Upon ligand binding, AR dissociates from accessory proteins, translocates into the nucleus, dimerizes, and stimulates transcription of androgen-responsive genes.
The AR signaling pathway is essential for male reproductive organ development and function, including the prostate and epididymis, and also affects nonreproductive tissues such as muscle, hair follicles, and brain. AR is a phosphoprotein and regulates MAP kinase activity. Inhibition of the MEK1/2 pathway alters AR phosphorylation. Dysregulation of AR signaling is linked to diseases including prostate cancer, Kennedy’s disease, and male infertility. Mutations can cause complete androgen insensitivity syndrome (CAIS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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