Thermo Fisher Scientific NOC3L Polyclonal Antibody
Rabbit polyclonal antibody against human NOC3L for Western blot applications. Recognizes internal region peptide of NOC3L. Supplied as liquid, unconjugated form at 1 mg/mL. Suitable for research use only.
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- PA539314
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- pk
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Thermo Fisher Scientific NOC3L Polyclonal Antibody
Applications
- Western Blot (WB): 1:500–1:1,000 dilution
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide derived from internal region of human NOC3L |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2555906 |
Target Information
GADD153 is a growth arrest and DNA damage-inducible gene encoding a C/EBP-related nuclear protein, also known as CHOP-10 or C/EBP zeta. Expression of GADD153 is induced by cellular stresses such as nutrient deprivation and metabolic perturbations. It functions to block cells in G1 to S phase during cell cycle progression by dimerizing with other C/EBP proteins, redirecting dimers from classical to nonclassical binding sites. Thus, GADD153 acts as a negative modulator of C/EBP-like proteins in certain differentiated cells.
GADD153 belongs to the CBF/MAK21 family, which includes NOC2L, NOC3L, and NOC4L. NOC3L, also known as factor for adipocyte differentiation 24 (Fad24), promotes adipogenesis by controlling DNA replication during early stages of mitotic clonal expansion (MCE).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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