Thermo Fisher Scientific NSG1 Polyclonal Antibody
Rabbit 폴리클로날 항체로 인간 NSG1 단백질을 인식합니다. Western blot에 사용 가능하며, 1:500~1:1,000 희석 권장. 액상 형태로 제공되며 -20°C 보관. 신경세포 내 수용체 재활용 연구에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide derived from the internal region of human NSG1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2555894 |
Target Information
NEEP21 (neuron-enriched endosomal 21kDa protein), also known as brain neuron cytoplasmic protein 1, NSG1 (neuron-specific proteins family member 1), P21, or D4S234E, is a single-pass type II membrane protein belonging to the NSG family.
It is highly expressed during neuronal maturation but its expression is downregulated in adult tissues.
NEEP21 predominantly localizes to Rab4-positive early endosomes in the somatodendritic neuronal compartment and is essential for proper receptor sorting and recycling in neurons.
It associates with GRIP1 and GluR-2 and mediates the surface expression of GluR-2. When this interaction is interrupted, GluR-2 accumulates in early endosomes and leads to changes in evoked synaptic current properties.
In addition, NEEP21 forms a complex with the SNARE protein Syntaxin 13 (also known as Syntaxin 12), and participates in the recycling of transferrin receptors (TFRs) and NTR2 (Neurotensin receptor 2).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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