Thermo Fisher Scientific PrP Polyclonal Antibody
Human PrP 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. IHC(P)에서 1:200–1:500 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 제공. 연구용으로만 사용.
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Thermo Fisher Scientific PrP Polyclonal Antibody
Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:200–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Protein corresponding to Human PrP. Recombinant protein control fragment (Product #RP-99454) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2856570 |
Product Specific Information
Immunogen sequence:
SDYEDRYYRE NMHRYPNQVY YRPMDEYSNQ NNFVHDCVNI TIKQHTVTTT TKGENFTETD VKMMERVVEQ MCITQYE
Target Information
Human prion protein (PrP), also known as PRNP, is a ubiquitously expressed GPI-anchored cell surface glycoprotein associating with lipid raft components and functioning as a signaling molecule. PrP plays a role in apoptosis in a cell context-dependent manner, is involved in proliferation of epithelial cells, and in distribution of junction-associated proteins in human enterocytes. Conversion of the normal cellular prion protein (PrPc) into an abnormal conformer (PrPSc) is the crucial step associated with triggering the pathogenesis of prion neurodegenerative disorders, such as Creutzfeld-Jakob disease (CJD). PrPc is rich in alpha-helices, whereas PrPSc has higher beta-sheet content and is resistant to proteinase K.
주의사항
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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