Thermo Fisher Scientific PRPK Monoclonal Antibody (OTI5A5)
PRPK 단백질을 인식하는 Mouse IgG2a 단일클론 항체로 Western blot 및 IHC(P) 실험에 적합. 인간 시료 반응성, 고순도 친화 크로마토그래피 정제. 액상 형태로 안정적이며 -20°C 보관 시 장기 보존 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5A5 |
| Immunogen | Full length human recombinant protein of TP53RK produced in E.coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2723520 |
Target Information
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:22912744, PubMed:27903914).
The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:22912744, PubMed:27903914).
TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP.
Atypical protein kinase that phosphorylates Ser-15 of p53/TP53 protein and may therefore participate in its activation (PubMed:11546806). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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