Thermo Fisher Scientific CD3 Recombinant Rabbit Monoclonal Antibody (JB38-29)
인간 CD3G 단백질을 표적으로 하는 재조합 토끼 단일클론 항체로, WB, IHC, Flow, IP 등 다양한 응용에 적합. HEK293 발현 시스템에서 생산되며 Protein A로 정제된 고순도 항체. 인간 조직 및 Jurkat 세포에 대한 양성 대조로 사용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:800 |
| Flow Cytometry (Flow) | 1:1,000 |
| Immunoprecipitation (IP) | 1:10–1:50 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JB38-29 |
| Immunogen | Synthetic peptide within Human CD3G aa 133–182 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2848600 |
Product Specific Information
Positive Control: Human tonsil tissue, human spleen tissue, mouse thymus tissue lysate, Jurkat cells.
Target Information
The CD3 subunit complex is crucial for transducing antigen-recognition signals into T cells and regulating surface expression of the TCR complex. Activation through the TCR involves CD3 gamma, delta, epsilon, and zeta subunits, which are structurally related members of the immunoglobulin superfamily encoded by closely linked genes on human chromosome 11.
CD3 components have long cytoplasmic tails that interact with signal transduction molecules via a double tyrosine-based motif. CD3 may contribute to TCR-induced growth arrest, survival, and proliferation. The CD3 antigen is expressed on 68–82% of normal peripheral blood lymphocytes, 65–85% of thymocytes, and Purkinje cells in the cerebellum, but not on B or NK cells.
Defects in CD3 genes are associated with CD3 immunodeficiency. Decreased T lymphocyte percentages may occur in autoimmune diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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