Thermo Fisher Scientific BID Monoclonal Antibody (OTI4A1), TrueMAB
인간 BID 단백질을 타깃으로 한 Mouse IgG1 단클론 항체로 Western blot, IHC, ICC/IF에 사용 가능. 고순도 친화 크로마토그래피 정제, PBS/BSA/glycerol 버퍼에 보관. 세포 사멸 연구용으로 적합하며 -20°C에서 안정적 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4A1 |
| Immunogen | Full length human recombinant protein of human BID produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
BID is a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. It is a member of the BCL-2 family of cell death regulators and mediates mitochondrial damage induced by caspase-8 (CASP8). CASP8 cleaves BID, and the COOH-terminal part translocates to mitochondria, triggering cytochrome c release and apoptosis. In living cells, BID exists in an inactive cytosolic form and becomes activated by caspase 8 in response to TNF alpha or Fas ligand. The cleaved C-terminal fragment (p15) translocates to mitochondria and initiates apoptosis, serving as a molecular link between caspase 8 activation and mitochondrial death machinery.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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