Thermo Fisher Scientific MAP4K3 Polyclonal Antibody
MAP4K3 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot, IHC, Flow cytometry에 적용 가능. Human과 Mouse 반응성. Protein A 정제, 0.5 mg/mL 농도, PBS buffer에 보관. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10–1:50 |
| Flow Cytometry (Flow) | 1:10–1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 501–529 amino acids from the central region of mouse MAP4K3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2634152 |
Product Specific Information
Predicted to react with rat based on sequence homology.
Target Information
MAP4K3 (also known as GLK) is a member of the STE20 family of serine/threonine protein kinases containing an N-terminal catalytic domain and a C-terminal regulatory domain. It acts upstream of MEKK1 and is stimulated by UV radiation and TNF-alpha, leading to activation of the JNK signaling pathway.
MAP4K3 can directly activate PKC-T during TCR signaling. Enhanced MAP4K3 expression and activation of PKC-T and IKK have been observed in T cells from individuals with systemic lupus erythematosus.
MAP4K3 functions as a pro-apoptotic kinase that activates BAX through modulation of PUMA, BAD, and BIM. Its kinase activity can be stimulated by UV radiation and TNF-alpha, specifically activating the c-Jun N-terminal kinase (JNK) pathway. It functions upstream of mitogen-activated protein kinase kinase 1 (MEKK1).
Previously known as RAB8-interacting protein-like 1 (RAB8IPL1), it has been renamed mitogen-activated protein kinase kinase kinase 3 (MAP4K3).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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