Thermo Fisher Scientific MSL1 Polyclonal Antibody
MSL1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot에 최적화되어 있으며 인간 시료에 반응. Protein A 및 항원 친화 크로마토그래피로 정제, PBS 버퍼에 보존. 연구용으로만 사용 가능.
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Thermo Fisher Scientific MSL1 Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 339–367 amino acids from the central region of human MSL1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2634147 |
Product Specific Information
Predicted to react with mouse based on sequence homology.
Target Information
Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at Lys-16 (H4K16ac), which is implicated in the formation of higher-order chromatin structure (PubMed:16227571).
Enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at Lys-34 (H2BK34Ub) (PubMed:21726816).
This modification stimulates histone H3 methylation at Lys-4 (H3K4me) and Lys-79 (H3K79me), leading to gene activation including HOXA9 and MEIS1 (PubMed:21726816).
In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed:22547026). [UniProt]
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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