Thermo Fisher Scientific Human Nogo-A Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 19 amino acids near the center of human NogoA.
PEP-0481 can be used as a blocking peptide with polyclonal antibody PA5-20367.

Target Information

NogoA is a member of a family of integral membrane proteins termed reticulons that are thought to be involved in numerous disorders including neurodegenerative diseases. Reticulon proteins regulate many cellular processes and interact with multiple proteins and receptors such as BACE.

NogoA was initially identified as a myelin-associated neurite outgrowth inhibitor. It is highly expressed in oligodendrocytes in the white matter of the CNS. Blocking its activity with antibodies or other factors results in improved axon regrowth and functional recovery in experimental CNS lesion models.

NogoA has also been suggested to play a role in neurodegenerative diseases such as Amyotrophic Lateral Sclerosis (ALS), in which case NogoA is found at elevated levels in postmortem muscular samples, and Multiple Sclerosis (MS), where autoantibodies to NogoA have been found in serum and cerebrospinal fluid of MS patients.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.