Thermo Fisher Scientific DMP1 Monoclonal Antibody (1D4)

Applications

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
ESIRSERGNS RMNSAGMKSK ESGENSEQAN TQDSGGSQLL EHPSRKIFRK SRISEEDDRS ELDDNNTMEE VKSDSTENSN SRDTGLSQPR RDSKGDSQED SKENLSQEES

Target Information

Dentin matrix acidic phosphoprotein (DMP1) is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. It plays a crucial role in bone and dentin mineralization and is found in various cells of bone and tooth tissues.
This protein has numerous acidic domains, multiple phosphorylation sites, an Arg-Gly-Asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts, DMP1 acts as a nuclear protein regulating osteoblast-specific gene expression. Upon maturation, it becomes phosphorylated and exported to the extracellular matrix, where it directs mineralized matrix formation.
Mutations in the DMP1 gene cause autosomal recessive hypophosphatemia, resulting in rickets and osteomalacia. The gene structure is conserved among mammals, with two transcript variants encoding different isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.