Thermo Fisher Scientific DMPK Monoclonal Antibody (2F7)

Applications

Tested Dilution

Publications

Western Blot (WB)

1-5 µg/mL

-

ELISA (ELISA)

0.03 ng/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a, kappa

Class

Monoclonal

Type

Antibody

Clone

2F7

Immunogen

DMPK (AAH62553, 303 a.a. approximately 420 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:DMPK,uniProtId:Q09013-9,ncbiNodeId:9606,antigenRange:303-420,antigenLength:629,antigenImageFileName:H00001760-M01_DMPK_Q09013-9_House_mouse.svg,antigenImageFileNamePDP:H00001760-M01_DMPK_Q09013-9_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: DEGVPEEARD FIQRLLCPPE TRLGRGGAGD FRTHPFFFGL DWDGLRDSVP PFTPDFEGAT DTCNFDLVED GLTAMVSGGG ETLSDIREGA PLGVHLPFVG YSYSCMALRD SEVPGPTP

Target Information

DMPK is a serine/threonine kinase expressed in various muscle and nerve tissues. Mutations in the untranslated region of the DMPK gene are a characteristic of myotonic dystrophy. The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3` untranslated region of this gene contains 5-37 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.