Thermo Fisher Scientific BAIAP2L1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Positive test controls include: HepG2, HeLa, 293T, A-549, Mouse lung.
The target is usually found in the following locations: Cytoplasm, cytoskeleton.

Immunogen sequence:
DKHCGFANHI HYYHLQSAEL LNSKLPRWQE TCVDAIKVPE KIMNMIEEIK TPASTPVSGT PQASPMIERS NVVRKDYDTL SKCSPKMPPA PSGRAYTSPL IDMFNNPATA APNSQRVNNS TGTSEDPSLQ RSVSVATGLN MMKKQKVKTI FPHTAGSNKT LLSFAQGDVI TLLIPEEKDG WLYGEHDVSK A

Target Information

This gene encodes a member of the IMD (IRSp53/MIM homology domain) family. Members of this family can be subdivided into two groups, IRSp53-like and MIM-like, based on the presence or absence of the SH3 (Src homology 3) domain.
The protein encoded by this gene contains a conserved IMD (F-actin bundling domain) at the N-terminus and a canonical SH3 domain near the C-terminus, thus belonging to the IRSp53-like group.
It acts as a substrate for insulin receptor tyrosine kinase and binds to the small GTPase Rac, participating in signal transduction pathways linking plasma membrane deformation and actin cytoskeleton remodeling.
Overexpression promotes actin assembly and membrane protrusions in mammalian cells and is essential for forming a potent actin assembly complex during EHEC (Enterohemorrhagic Escherichia coli) pedestal formation.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.