Thermo Fisher Scientific Phospho-GRLF1 (Tyr1087) Polyclonal Antibody
Phospho-GRLF1 (Tyr1087) 폴리클로날 항체로 사람, 마우스, 랫트 시료에 반응합니다. IHC, ICC/IF, ELISA 등 다양한 응용에 적합하며 고순도의 Protein A 정제 항체입니다. 연구용으로만 사용되며 안정적인 액상 형태로 -20°C 보관됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthesized phosphopeptide derived from human GRLF1 around the phosphorylation site of Tyr1087 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
RNA polymerase (Pol) III synthesizes tRNA, 5S rRNA, 7SL RNA, and U6 snRNA, and is overexpressed in many transformed cell lines and tumors. To maintain rapid growth, cells require high levels of Pol III-transcribed RNA, dependent on TFIIIB and TFIIIC2 transcription factor complexes.
TFIIIC2 consists of five subunits (TFIIIC220, TFIIIC110, TFIIIC102, TFIIIC90, TFIIIC63), which are overexpressed in adenovirus-transformed and malignant cells such as ovarian carcinomas.
TFIIIC2 recruits RNA Pol III and TFIIIB to promoter elements, potentially contributing to malignant cell deregulation. TFIIIB includes TBP, BRF1 (TFIIIB90), and TFIIIB subunits, whose expression is upregulated in transformed cells.
In many carcinomas, tumor suppressors RB and p53 are inactivated, affecting their ability to bind and inhibit TFIIIB function.
For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.
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