Thermo Fisher Scientific APC1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.04–0.4 µg/mL
• Publications: [References not provided]

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:200–1:500
• Publications: [References not provided]

Product Specifications

Product Specific Information

Immunogen sequence:
PPRNTTVDLN SGNIDVPPNM TSWASFHNGV AAGLKIAPAS QIDSAWIVYN KPKHAELANE YAGFLMALGL NGHLTKLATL NIHDYLTKGH

Target Information

Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis.
APC1, also known as mitotic checkpoint regulator (MCPR), is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.
APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence.
The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.