Thermo Fisher Scientific Brevican Monoclonal Antibody (450613)
인간 Brevican 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot, Immunoprecipitation 및 Neutralization에 사용 가능. 단백질 A/G로 정제된 동결건조 형태이며, PBS + trehalose 버퍼에 재구성. 뇌 ECM 연구 및 신경가소성 관련 연구용.
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Thermo Fisher Scientific Brevican Monoclonal Antibody (450613)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunoprecipitation (IP) | 25 µg/mL |
| Neutralization (Neu) | Assay-Dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 450613 |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant human Brevican isoform 1 (Asp23–Pro911) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2606085 |
Product Specific Information
- This antibody also detects a truncated version of recombinant human Brevican (aa 23–649).
- Reconstitute at 0.5 mg/mL in sterile PBS.
- Endotoxin level is <0.10 EU per 1 µg of antibody by the LAL method.
Target Information
Brevican is the most abundant chondroitin sulfate proteoglycan in the extracellular matrix of the adult brain. It belongs to the lectican family of aggregating extracellular matrix proteoglycans bearing chondroitin sulfate (CS) chains. Highly expressed in the central nervous system, Brevican is thought to stabilize synapses and inhibit neural plasticity.
It is secreted from astrocytes and neurons as a 145 kD core protein that may bear up to three covalently-linked CS chains, or as a core protein without CS chains. When cleaved by extracellular glutamyl endopeptidases (ADAMTSs), a 55 kD N-terminal fragment containing the unique C-terminal epitope EAMESE is formed.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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