Thermo Fisher Scientific SPRY2 Polyclonal Antibody
SPRY2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB 및 ICC/IF에 적합. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol 버퍼에 보관. 인간 SPRY2에 반응하며 연구용으로 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human SPRY2. Recombinant protein control fragment (Product #RP-106022) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2662127 |
Product Specific Information
Immunogen sequence:
PTVVPRPGLKP APRPSTQHKH ERLHGLPEHR QPPRLQHSQV HSSARAPLSR SISTVSSGSR SSTRTSTSSS SSEQ
Highest antigen sequence identity to the following orthologs:
- Mouse: 97%
- Rat: 93%
Target Information
This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles.
In primary dermal endothelial cells, this gene is transiently upregulated in response to fibroblast growth factor 2. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor 2 signaling.
The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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