Thermo Fisher Scientific IDO1 Monoclonal Antibody (10.1)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use.

This antibody is specific for human and mouse IDO1 protein. A BLAST analysis suggests cross-reactivity with IDO1 from human and mouse sources based on 100% homology with the immunizing sequence. Cross-reactivity with IDO1 from other species has not been determined.

Target Information

IDO1 is an intracellular heme-containing enzyme that catalyzes the oxidative cleavage of the indole ring of regulatory molecules such as tryptophan, serotonin, and melatonin. This reaction initiates the production of biologically active metabolites known as kynurenines.
IDO1 is expressed in various human tissues, macrophages, and dendritic cells. Inflammatory cytokines like interferons (IFNs) induce IDO1 expression, contributing to antimicrobial defense by degrading tryptophan, thereby inhibiting the growth of viruses, bacteria, and parasites.
Additionally, IDO1 plays an essential role in immunoregulation during infection, pregnancy, autoimmunity, transplantation, and cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.