Thermo Fisher Scientific IDO1 Monoclonal Antibody (10.1)
IDO1 단백질을 인식하는 Mouse Monoclonal Antibody (Clone 10.1). Western blot, IHC, ELISA, IP 등 다양한 응용에 적합. Human 및 Mouse 반응성. Protein G 정제, 1 mg/mL 농도의 액상 형태로 제공. 연구용으로만 사용 가능.
- 카탈로그번호
- 200-301-E57x (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific IDO1 Monoclonal Antibody (10.1)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,500 |
| Immunohistochemistry (IHC) | 1:100–1:500 |
| ELISA | 1:5,000–1:50,000 |
| Immunoprecipitation (IP) | 10–100 µL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG3 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 10.1 |
| Immunogen | Anti-IDO1 (MOUSE) Monoclonal Antibody was produced in mouse by repeated immunizations with fragment of recombinant human and mouse IDO1 protein followed by hybridoma development. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | 0.02M potassium phosphate, pH 7.2, with 0.15M NaCl |
| Contains | 0.01% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use.
This antibody is specific for human and mouse IDO1 protein. A BLAST analysis suggests cross-reactivity with IDO1 from human and mouse sources based on 100% homology with the immunizing sequence. Cross-reactivity with IDO1 from other species has not been determined.
Target Information
IDO1 is an intracellular heme-containing enzyme that catalyzes the oxidative cleavage of the indole ring of regulatory molecules such as tryptophan, serotonin, and melatonin. This reaction initiates the production of biologically active metabolites known as kynurenines.
IDO1 is expressed in various human tissues, macrophages, and dendritic cells. Inflammatory cytokines like interferons (IFNs) induce IDO1 expression, contributing to antimicrobial defense by degrading tryptophan, thereby inhibiting the growth of viruses, bacteria, and parasites.
Additionally, IDO1 plays an essential role in immunoregulation during infection, pregnancy, autoimmunity, transplantation, and cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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