Thermo Fisher Scientific AR Monoclonal Antibody (OTI2E6), TrueMAB
인간 AR 단백질(아미노산 420-659)에 특이적인 마우스 IgG1 단클론 항체입니다. Western blot과 파라핀 절편 면역조직화학에 사용 가능하며, 액상 형태로 1 mg/mL 농도입니다. 연구용으로만 사용되며, -20°C에서 보관합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2E6 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 420–659 of human AR produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. It has three major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. AR acts as a ligand-activated transcription factor that binds testosterone (T) and dihydrotestosterone (DHT). Upon ligand binding, the receptor translocates into the nucleus, dimerizes, and stimulates transcription of androgen-responsive genes.
AR signaling is essential for development and function of male reproductive organs such as the prostate and epididymis, and also plays roles in muscle, hair follicles, and brain. AR is a phosphoprotein that regulates MAP kinase activity; inhibition of MEK1/2 affects AR phosphorylation. Abnormal AR signaling is linked to diseases including prostate cancer, Kennedy’s disease, and male infertility. Mutations in AR gene are associated with complete androgen insensitivity syndrome (CAIS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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