Thermo Fisher Scientific NPR2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:3,000
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Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200
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Product Specifications

Product Specific Information

Antibody detects endogenous levels of total NPR2.

Target Information

This gene encodes natriuretic peptide receptor B (NPR2), one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains:

• Extracellular ligand-binding domain
• Single membrane-spanning region
• Intracellular protein kinase homology domain
• Helical hinge region involved in oligomerization
• Carboxyl-terminal guanylyl cyclase catalytic domain

The protein is the primary receptor for C-type natriuretic peptide, which upon ligand binding exhibits greatly increased guanylyl cyclase activity.
Mutations in this gene are associated with acromesomelic dysplasia Maroteaux type.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.