Thermo Fisher Scientific SERPINA12 Polyclonal Antibody, MaxPab
SERPINA12 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot에 적합하며, 인간 시료 반응성을 가짐. 액상 형태로 제공되며, PBS 버퍼에 보존제 없이 -20°C에서 보관. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): Tested dilution 1–5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | SERPINA12 (NP_776249.1, 1–414 a.a.) full-length human protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MNPTLGLAIF LAVLLTVKGL LKPSFSPRNY KALSEVQGWK QRMAAKELAR QNMDLGFKLL KKLAFYNPGR NIFLSPLSIS TAFSMLCLGA QDSTLDEIKQ GFNFRKMPEK DLHEGFHYII HELTQKTQDL KLSIGNTLFI DQRLQPQRKF LEDAKNFYSA ETILTNFQNL EMAQKQINDF ISQKTHGKIN NLIENIDPGT VMLLANYIFF RARWKHEFDP NVTKEEDFFL EKNSSVKVPM MFRSGIYQVG YDDKLSCTIL EIPYQKNITA IFILPDEGKL KHLEKGLQVD TFSRWKTLLS RRVVDVSVPR LHMTGTFDLK KTLSYIGVSK IFEEHGDLTK IAPHRSLKVG EAVHKAELKM DERGTEGAAG TGAQTLPMET PLVVKIDKPY LLLIYSEKIP SVLFLGKIVN PIGK
Target Information
Vaspin is a newly described adipocytokine expressed predominantly in visceral white adipose tissues. Structure analysis predicts three beta-sheets, nine alpha-helices, and one central loop, characteristic of Serpin family members. Serpins are irreversible serine-protease inhibitors with >30% sequence homology to alpha1-antitrypsin and a conserved tertiary structure containing an exposed reactive center loop acting as a pseudo-substrate.
Members of this family are involved in blood coagulation, fibrinolysis, complement activation, angiogenesis, inflammation, and tumor suppression. In humans, serpins represent ~2% of total serum proteins, with 70% being alpha1-antitrypsin. Vaspin exhibits 40.2% sequence identity with alpha1-antitrypsin, though its protease inhibitory activity is still unknown.
Vaspin mRNA expression in visceral fat correlates positively with BMI and body fat percentage. Administration of vaspin to obese mice improved glucose tolerance and insulin sensitivity, normalizing blood glucose levels and reversing altered expression of diabetes-related adipocytokines (leptin, adiponectin, resistin, TNF-alpha). These findings suggest potential clinical applications for Vaspin in diabetes/obesity metabolic syndrome research.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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