Thermo Fisher Scientific DDX3 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human DDX3 protein. Validated for WB and IP applications. Predicted cross-reactivity with mouse, orangutan, and chimpanzee. Supplied as liquid at 1 mg/mL, stored at 4°C. For research use only.
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Applications
| Application | Tested Dilution / Amount |
|---|---|
| Western Blot (WB) | 1:5,000–1:15,000 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 600 and the C-terminus (residue 661) of human DEAD (Asp-Glu-Ala-Asp) box polypeptide 3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Mouse, Orangutan, and Chimpanzee
Target Information
The protein encoded by this gene belongs to the large DEAD-box protein family, characterized by the conserved Asp-Glu-Ala-Asp (DEAD) motif and ATP-dependent RNA helicase activity. It exhibits RNA-independent ATPase activity and is stimulated by both RNA and DNA. DDX3 functions in both the nucleus and cytoplasm, contributing to transcriptional regulation, mRNP assembly, pre-mRNA splicing, mRNA export, translation, cellular signaling, and viral replication. Misregulation of DDX3 has been implicated in tumorigenesis. The gene has a paralog on the Y chromosome (DDX3Y), and related pseudogenes exist on chromosomes 4 and X. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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