Thermo Fisher Scientific CD4 Polyclonal Antibody
CD4 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot, IHC, Flow cytometry 등 다양한 응용 가능. Human, Mouse, Rat 반응성. KLH 결합 합성 펩타이드(aa 301-400) 면역원 사용. 고순도 Protein A 정제, -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Flow Cytometry (Flow) | 1:20–1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human CD4, amino acids 301–400 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The CD4 antigen is involved in the recognition of MHC class II molecules and acts as a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes (T helper cells) and may also be found in monocytes, macrophages, and dendritic cells. At the tissue level, expression occurs in thymus, lymph nodes, tonsils, spleen, and specific regions of the brain and gut.
CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase Lck. It may also play a role as a mediator of neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcripts have been identified in this gene (RefSeq, July 2017).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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