Thermo Fisher Scientific TDP1 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human TDP1 protein. Validated for IHC and IHC-P applications. Supplied as a liquid, unconjugated form at 0.25 mg/mL. Stored at 4°C with 1-year shelf life. For research use only.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (IHC) | 1:100–1:500 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:500 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1 and 50 of Human tyrosyl-DNA phosphodiesterase 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Orangutan, Gorilla, and Chimpanzee
Target Information
The protein encoded by this gene is involved in repairing stalled topoisomerase I–DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3′ phosphate of DNA.
It may also remove glycolate from single-stranded DNA containing 3′ phosphoglycolate, suggesting a role in repair of free-radical–mediated DNA double-strand breaks.
This gene belongs to the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations are associated with spinocerebellar ataxia with axonal neuropathy (SCAN1). Two major transcript variants encoding the same isoform have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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