Thermo Fisher Scientific IPO5 Polyclonal Antibody
Human IPO5 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P)에서 1:20–1:50 희석 비율로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보관. 핵공 복합체 내 단백질 수입 과정 연구에 적합.
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Applications and Tested Dilution
- Immunohistochemistry (Paraffin) (IHC (P)): 1:20–1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human IPO5. Recombinant protein control fragment (Product # RP-102903) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2642754 |
Product Specific Information
- Immunogen sequence:
AAEQQQFYLL LGNLLSPDNV VRKQAEETYE N - Antigen sequence identity:
Mouse – 100%, Rat – 100%
Target Information
Nucleocytoplasmic transport is a signal- and energy-dependent process occurring through nuclear pore complexes in the nuclear envelope. Import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits (karyopherins). Importin alpha binds the NLS-containing cargo in the cytoplasm, while importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. With nucleoside triphosphates and Ran GTPase, the complex translocates into the nucleus where importin subunits dissociate. Importin beta remains at the pore, and interactions with FG repeats of nucleoporins are essential for translocation. The encoded protein belongs to the importin beta family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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