Thermo Fisher Scientific IL5RA Polyclonal Antibody
IL5RA 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody입니다. 인간, 마우스, 랫트 반응성이 있으며 Western Blot과 ELISA에 사용 가능합니다. 고순도 친화 크로마토그래피 정제, 액상 형태로 제공되며 연구용으로 적합합니다.
- 카탈로그번호
- PA5121210
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 20–335 of human IL5RA (NP_783855.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.54 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914782 |
Product Specific Information
Positive test controls include HL-60, B cells, U-87MG, Mouse liver, Mouse lung, and Rat lung.
The target is typically localized to the membrane as a single-pass type I membrane protein.
Immunogen sequence:
ADLLPDEKIS LLPPVNFTIK VTGLAQVLLQ WKPNPDQEQR NVNLEYQVKI NAPKEDDYET RITESKCVTI LHKGFSASVR TILQNDHSLL ASSWASAELH APPGSPGTSI VNLTCTTNTT EDNYSRLRSY QVSLHCTWLV GTDAPEDTQY FLYYRYGSWT EECQEYSKDT LGRNIACWFP RTFILSKGRD WLAVLVNGSS KHSAIRPFDQ LFALHAIDQI NPPLNVTAEI EGTRLSIQWE KPVSAFPIHC FDYEVKIHNT RNGYLQIEKL MTNAFISIID DLSKYDVQVR AAVSSMCREA GLWSEWSQPI YVGFSR
Target Information
Interleukin 5 (IL-5) is a soluble T cell-derived factor that induces B cell and eosinophil growth and differentiation.
IL-5 exerts its biological activity through the IL-5 receptor (IL-5R), composed of two chains:
- Alpha chain: binds IL-5 with low affinity
- Beta chain: forms high-affinity receptor complex with alpha chain
The cytoplasmic domains of both chains are essential for signal transduction.
The membrane-proximal proline-rich sequence of the IL-5Rα cytoplasmic domain is critical for IL-5–induced proliferation, nuclear proto-oncogene expression, and tyrosine phosphorylation of proteins such as JAK1 and JAK2.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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