Thermo Fisher Scientific CYP46A1 Polyclonal Antibody
CYP46A1 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat 시료에 반응합니다. Western blot, ICC/IF, ELISA에 사용 가능하며, 고순도 Affinity Chromatography로 정제되었습니다. 뇌 조직 내 콜레스테롤 대사 연구에 적합합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:100 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 24–280 of human CYP46A1 (NP_006659.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.9 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914783 |
Product Specific Information
- Positive test controls: U-87MG, U-251MG, MCF7, Mouse liver, Mouse brain, Rat liver
- Subcellular localization: Endoplasmic reticulum membrane, Microsome membrane, Single-pass membrane protein
Immunogen sequence:
HRARSRYEHI PGPPRPSFLL GHLPCFWKKD EVGGRVLQDV FLDWAKKYGP VVRVNVFHKT SVIVTSPESV KKFLMSTKYN KDSKMYRALQ TVFGERLFGQ GLVSECNYER WHKQRRVIDL AFSRSSLVSL METFNEKAEQ LVEILEAKAD GQTPVSMQDM LTYTAMDILA KAAFGMETSM LLGAQKPLSQ AVKLMLEGIT ASRNTLAKFL PGKRKQLREV RESIRFLRQV GRDWVQRRRE ALKRGEEVPA DILTQIL
Target Information
The CYP46A1 gene encodes a cytochrome P450 enzyme involved in cholesterol metabolism in the brain. It converts cholesterol to 24S-hydroxycholesterol, which can cross the blood-brain barrier and be transported to the liver for catabolism. This enzyme is a key component in maintaining cholesterol homeostasis in neural tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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