Thermo Fisher Scientific CYP46A1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

Immunocytochemistry (ICC/IF)

1:50-1:100

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 24-280 of human CYP46A1 (NP_006659.1). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CYP46A1,uniProtId:Q9Y6A2-1,ncbiNodeId:9606,antigenRange:24-280,antigenLength:500,antigenImageFileName:PA5-121211_CYP46A1_Q9Y6A2-1_Rabbit.svg,antigenImageFileNamePDP:PA5-121211_CYP46A1_Q9Y6A2-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.9 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2914783

Product Specific Information

Positive test controls include: U-87MG, U-251MG, MCF7, Mouse liver, Mouse brain, Rat liver. The target is usually found in the following locations: Endoplasmic reticulum membrane, Microsome membrane, Single-pass membrane protein.

Immunogen sequence: HRARSRYEHI PGPPRPSFLL GHLPCFWKKD EVGGRVLQDV FLDWAKKYGP VVRVNVFHKT SVIVTSPESV KKFLMSTKYN KDSKMYRALQ TVFGERLFGQ GLVSECNYER WHKQRRVIDL AFSRSSLVSL METFNEKAEQ LVEILEAKAD GQTPVSMQDM LTYTAMDILA KAAFGMETSM LLGAQKPLSQ AVKLMLEGIT ASRNTLAKFL PGKRKQLREV RESIRFLRQV GRDWVQRRRE ALKRGEEVPA DILTQIL

Target Information

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.