Thermo Fisher Scientific CCDC98 Polyclonal Antibody, FITC
FITC 결합형 CCDC98 폴리클로날 항체로 BRCA1-A 복합체 연구에 적합. 마우스와 랫트 반응성, Rabbit IgG 호스트. Western blot, ELISA, IP 등 다양한 응용 가능. 액상 형태로 -20°C 암저장.
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Thermo Fisher Scientific CCDC98 Polyclonal Antibody, FITC
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 350–400 on rat BRCA1-A complex subunit Abraxas protein |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer (pH 7.4–7.8) with 0.5% BSA, 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CCDC98, also known as Abraxas 1, was identified through protein binding studies using the breast and ovarian predisposition protein BRCA1 as the binding target.
CCDC98 recruits RAP80, a ubiquitin-binding protein, to BRCA1, enabling formation of BRCA1 foci in response to DNA damage caused by ionizing radiation.
Both CCDC98 and RAP80 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair.
Cells depleted of either CCDC98 or RAP80 exhibit increased sensitivity to ionizing radiation, though not as much as BRCA1-depleted cells, suggesting that CCDC98 and RAP80 control only part of BRCA1’s DNA damage response role.
At least two isoforms of CCDC98 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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