Thermo Fisher Scientific CCDC98 Polyclonal Antibody
CCDC98(Abraxas 1) 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ELISA, IP 등 다양한 응용에 적합. BRCA1 복합체 관련 DNA 손상 반응 연구용. 고순도 친화 크로마토그래피 정제 및 안정적 액상 형태.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:100 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 350–400 of rat BRCA1-A complex subunit Abraxas protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 0.5% BSA, 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CCDC98, also known as Abraxas 1, is a BRCA1-binding protein involved in DNA damage response. It recruits RAP80 to BRCA1, enabling BRCA1 foci formation after ionizing radiation. Both CCDC98 and RAP80 are essential for DNA damage resistance, G2-M checkpoint control, and DNA repair. Depletion of either increases sensitivity to radiation, though less than BRCA1 depletion, indicating partial control of BRCA1’s DNA damage response. At least two isoforms of CCDC98 are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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