Thermo Fisher Scientific Phospho-c-Cbl (Tyr774) Recombinant Rabbit Monoclonal Antibody (CblY774-R3B8), PE
PE 형광 표지된 인산화 c-Cbl (Tyr774) 특이 재조합 토끼 단클론 항체. 인간 및 마우스 시료에 반응하며, Flow Cytometry에 적합. 고순도 Protein A/G 정제, 안정적 PBS/BSA 완충액 보존. 연구용으로 세포 신호 조절 연구에 활용 가능.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: 5 µL / 1×10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | CblY774-R3B8 |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Tyr774 of human phospho c-Cbl |
| Conjugate | PE (R-Phycoerythrin) |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.20% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2897282 |
Additional Formats
Target Information
Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation.
Cbl-c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells, while other Cbl proteins are ubiquitously expressed.
Cbl-c can ubiquitinate activated EGFR and target it for degradation.
Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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