Thermo Fisher Scientific FBXW5 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human FBXW5. Recombinant protein control fragment (Product #RP-102197). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:FBXW5,uniProtId:Q969U6-1,ncbiNodeId:9606,antigenRange:412-523,antigenLength:566,antigenImageFileName:PA5-61259_FBXW5_Q969U6-1_Rabbit.svg,antigenImageFileNamePDP:PA5-61259_FBXW5_Q969U6-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2641562

Product Specific Information

Immunogen sequence: PDNRYLYVNS RAWPNGAVVA DPMQPPPIAE EIDLLVFDLK TMREVRRALR AHRAYTPNDE CFFIFLDVSR DFVASGAEDR HGYIWDRHYN ICLARLRHED VVNSVVFSPQ EQ

Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 96%.

Target Information

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.