Thermo Fisher Scientific Amphiregulin Monoclonal Antibody (A5)
인간 Amphiregulin을 인식하는 Mouse 모노클로날 항체로 Western blot 및 IHC(P) 적용 가능. Recombinant Amphiregulin(aa 20-100)을 면역원으로 사용. Protein A/G 정제, PBS+50% glycerol 저장, -20°C 보관. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 0.01–4 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 5–20 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | A5 |
| Immunogen | Recombinant protein Amphiregulin (aa 20–100 of target protein) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899031 |
Target Information
Amphiregulin (AR) binds to the EGF receptor (EGFR) with lower affinity than EGF. The mature secreted AR is an 84-amino acid glycosylated growth regulator derived from a 252-amino acid transmembrane precursor. Seven distinct ligands, including EGF, TGFα, AR, HB-EGF, cripto-1, epiregulin, and betacellulin, can bind to the extracellular domain of EGFR. These ligands share a characteristic EGF-like domain defined by six cysteine residues forming three disulfide-bonded loops. AR protein is localized in epithelial tissues such as colon, stomach, pancreas, breast, and placenta, and is overexpressed in several human cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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