Thermo Fisher Scientific Pan Ras Recombinant Rabbit Monoclonal Antibody (ARC2369)
Pan Ras 단백질을 인식하는 재조합 토끼 단클론 항체로, 인간·마우스·랫트 시료에 반응합니다. Western blot, ICC/IF, ELISA에 적합하며 고순도 친화 크로마토그래피 정제 제품입니다. 신호전달 및 암 관련 Ras 연구용으로 권장됩니다.
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Thermo Fisher Scientific Pan Ras Recombinant Rabbit Monoclonal Antibody (ARC2369)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:400 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC2369 |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–188 of human NRAS (P01111) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.45 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2897912 |
Product Specific Information
- Positive samples: HT-29, 293T, MCF7, NIH/3T3, C6, Mouse lung, Mouse brain, Rat brain
- Immunogen sequence:
MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET CLLDILDTAG QEEYSAMRDQ YMRTGEGFLC VFAINNSKSF ADINLYREQI KRVKDSDDVP MVLVGNKCDL PTRTVDTKQA HELAKSYGIP FIETSAKTRQ GVEDAFYTLV REIRQYRMKK LNSSDDGTQG CMGLPCVV
Target Information
This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus.
Mutations in this gene cause Costello syndrome, characterized by prenatal overgrowth, postnatal growth deficiency, tumor predisposition, mental retardation, and various abnormalities. Defects in this gene are implicated in cancers such as bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma.
Multiple transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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