Thermo Fisher Scientific ARC VHH-8His-Cys-tag Recombinant Alpaca Monoclonal Antibody (SAA1466)
ELISA 및 중화 실험에 적합한 알파카 유래 재조합 단일클론 항체. Rat ARC 단백질 인식. CHO 세포 발현, 금속 킬레이트 크로마토그래피로 정제. 1 mg/mL 농도, PBS 용액, 방부제 무첨가. 단기 4°C, 장기 -20°C 보관 권장.
- 카탈로그번호
- MA554775
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- pk
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Applications
ELISA (ELISA)
- Tested Dilution: Assay-dependent
Neutralization (Neu)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rat |
| Host / Isotype | Alpaca / VHH |
| Expression System | CHO cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SAA1466 |
| Immunogen | Recombinant Rat ARC |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Metal-chelate chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
Product Specific Information
- Compatible with Direct ELISA
Target Information
ARC (also known as NOL3 - Nucleolar protein 3) has two isoforms. Isoform 1 is involved in RNA splicing, while Isoform 2 functions as an apoptosis repressor that blocks multiple modes of cell death.
ARC inhibits extrinsic apoptotic pathways by:
- Interacting with FAS and FADD upon FAS activation, blocking death-inducing signaling complex (DISC) assembly.
- Interacting with CASP8 in a mitochondria localization- and phosphorylation-dependent manner, limiting soluble CASP8 available for DISC-mediated activation.
ARC also inhibits intrinsic apoptotic pathways in response to various stresses through interactions with BAX, resulting in BAX inactivation and prevention of mitochondrial dysfunction and release of pro-apoptotic factors.
Mutations affecting this gene can result in myoclonus, familial cortical.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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