Thermo Fisher Scientific ARC VHH-8His-Cys-tag Recombinant Alpaca Monoclonal Antibody (SAA1467)

Applications

ELISA (ELISA)

• Tested Dilution: Assay-dependent

Neutralization (Neu)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

• Compatible with Direct ELISA

Target Information

ARC (also known as NOL3 - Nucleolar protein 3) has two isoforms.

• Isoform 1: Involved in RNA splicing.
• Isoform 2: Functions as an apoptosis repressor that blocks multiple modes of cell death.

ARC inhibits extrinsic apoptotic pathways in two ways:

1. Interacting with FAS and FADD upon FAS activation, blocking death-inducing signaling complex (DISC) assembly.
2. Interacting with CASP8 in a mitochondria localization- and phosphorylation-dependent manner, limiting soluble CASP8 available for DISC-mediated activation.

ARC also inhibits intrinsic apoptotic pathways in response to various stresses through interactions with BAX, resulting in BAX inactivation and preventing mitochondrial dysfunction and release of pro-apoptotic factors.
Mutations affecting the gene can result in myoclonus, familial cortical disorders.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.