Thermo Fisher Scientific TREX1 Polyclonal Antibody
TREX1 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체. Western blot과 IHC에 사용 가능하며, 인간, 마우스, 랫트 시료에 반응. 항원 친화 크로마토그래피로 정제된 고순도 항체로, PBS 용액에 0.02% sodium azide를 포함. 연구용 전용 제품.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5–1 µg/mL |
| Immunohistochemistry (IHC) | 2.5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 15 amino acid peptide near the center of human TREX1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11155979 |
Product Specific Information
A suggested positive control is human spleen tissue lysate.
PA5-20665 can be used with blocking peptide PEP-0785.
Target Information
Trex1 (ATRIP) is the major human 3′ to 5′ exonuclease required for checkpoint signaling after DNA damage. It is ubiquitously expressed and binds to single-stranded DNA coated with replication protein A at sites of DNA damage, recruiting ATR (ataxia telangiectasia and Rad3 related protein), a checkpoint kinase, to these sites. Trex1 is essential for ATR expression.
This gene uses two different open reading frames:
- The upstream ORF encodes proteins that interact with ATR and localize to intranuclear foci induced by DNA damage.
- The downstream ORF encodes proteins with 3′ to 5′ exonuclease activity, possibly a subunit of human DNA polymerase III.
Multiple transcript variants encoding different isoforms have been identified. Mutations in this gene are associated with Aicardi-Goutières syndrome, chilblain lupus, and Cree encephalitis.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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