Thermo Fisher Scientific TREX1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

A suggested positive control is human spleen tissue lysate.
PA5-20665 can be used with blocking peptide PEP-0785.

Target Information

Trex1 (ATRIP) is the major human 3′ to 5′ exonuclease required for checkpoint signaling after DNA damage. It is ubiquitously expressed and binds to single-stranded DNA coated with replication protein A at sites of DNA damage, recruiting ATR (ataxia telangiectasia and Rad3 related protein), a checkpoint kinase, to these sites. Trex1 is essential for ATR expression.
This gene uses two different open reading frames:

• The upstream ORF encodes proteins that interact with ATR and localize to intranuclear foci induced by DNA damage.
• The downstream ORF encodes proteins with 3′ to 5′ exonuclease activity, possibly a subunit of human DNA polymerase III.

Multiple transcript variants encoding different isoforms have been identified. Mutations in this gene are associated with Aicardi-Goutières syndrome, chilblain lupus, and Cree encephalitis.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.