Thermo Fisher Scientific ROBO1 Recombinant Mouse Monoclonal Antibody (22D5)

Applications and Tested Dilution

Product Specifications

Target Information

Specialized cells at the midline, which separates the left and right halves of the CNS, have roles in directing growth cone behavior. In vertebrate spinal cord, insect ventral nerve cord, and C. elegans, midline cells produce guidance cues such as nectins and slit, which act as attractants and repellents. These cells function as gatekeepers to regulate axon crossing and responsiveness.

Robo is an axon guidance receptor of the Ig superfamily, conserved from fruit flies to mammals. It acts as a receptor for the repellent Slit and functions in a cell-autonomous manner. Non-crossing axons express high levels of Robo, while crossing axons show dynamic expression changes before and after midline crossing. Robo1 and Robo2 are human homologs of the Drosophila Roundabout protein; Robo1 is homologous to the C. elegans gene sax3, and Robo2 to the zebrafish gene astray.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.